Pair Name	Dihydrotanshinone I, Cisplatin
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	MAD2L1	hsa4085
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	SW1736	Thyroid gland anaplastic carcinoma	Homo sapiens (Human)	CVCL_3883
	8505C	Thyroid gland anaplastic carcinoma	Homo sapiens (Human)	CVCL_1054
Result	The present study is the first to demonstrate that DHT exerts antitumor effects on ATC cells by reducing MAD2 expression levels. Moreover, a synergistic effect of DHT with cisplatin was shown. Further in vivo studies are required to assess this phytochemical compound as a potential adjuvant for the treatment of ATC.